Just had a look at my logbook. I haven't been to Australia since December and haven't been to North America since September last year. However, on a reserve month I could have to go to either of these places with only 30 minutes notice. That is different to flying around Europe in a 320 on a couple of sectors every day. Not really harder, just different. Flying the aeroplane is the easy bit.
Absoultely agree with what The Don says, you can train a DEC to be a widebody pilot but a LCC short haul manager will never, ever know what it is like.