737 cockpit is definitely not a comfortable place to be, but I wouldn’t base a career choice on that, particularly for short haul.
I think base is a high priority because you need to be with friends and family, otherwise what’s the point right? A good salary and roster, can become pretty average if you end up paying for a mortgage at home and rent where you’re based, and commuting on a 5/4 Roster soon can become a fatiguing 7/2. So, it really depends on your own personal circumstances and priorities.
I wouldn't recommend Ryanair to anyone, but in truth, it’s a good enough platform for your first jet job, if there are no better options of course, I don’t know much about Vueling, but I’ve heard the pay is rubbish. If you get good money and roster with the possibility of getting to your home base within a reasonable timescale, it’s probably a no brainer.
Good luck! Would be interesting to know what decision you make eventually.