This thread moved from 'direct connections to the Americas and mainland Europe' to a few extra seats from Anglesey very quickly. This may say something about the potential for such an airline.
Call me old-fashioned but last time I checked Angelsey was in Wales, the OP didn't specify CWL, Hawarden, Canaefon, Aberporth, Swansea nor any of the others that I can't be bothered to recall the identities of.