For 'first time' of a new design I would agree with above comments of quick tests followed by inspections with an added caveat of using a current limiting bench supply set to expected full load X 1.5 or so.
This helps prevent thermal events caused by backward caps etc.
Will not save the part in many cases but can prevent melted traces or burned board.
If the supply current limits find out why before proceeding.
Also a careful inspection and reality check measurements with an ohm meter that has high and low sense voltages before applying power.
Do this for every internal voltage rail to ground.
Also check rail to rail! Got literally burned by a short between 2 rails once...
If you have multiple boards measure all of them first and account for any significant differences. If practical allways build at least 3 so you have a tie breaker
In any case log the values as reference for the next batch.
The low voltage will not activate semi junctions and will detect shorts and should match a rough calculated expected value, usually fairly high (> 1K) unless bus termination resistor networks connect to both power and ground.
Often you can see the big bypass caps charging so initial reading will be low then quickly climb. Reversing the leads will show the same effect
The 'high', often shown as diode test on the cheap meters, helps detect backward diodes etc, this sometimes takes a bit of digging to understand if not as expected.
If possible bring up the board without the expensive parts first, often not practical unless sockets can be used on first proto.
Connected every meter and scope channel you own to the power rails and watch carefully on power up, especially confusing are sub regulaters that appear about right but are actually cycling between shutdown and overvoltage.
Lastly once the power is OK suspect anything with the word "I2C" in it.