Mentally and physically, I reckon 36 years flying was less tiring and damaging than , say, 36 years working in a steel mill or down a coal mine....But much more so than 36 years working a 9 to 5 office job, five days every week, no weekends, etc....
Having said that....All 36 years were on TPs and undoubtedly resulted in what is now impaired hearing - not deafness, but my final medical a couple of years ago, the Dr told me that I now have only about 55% hearing levels compared to that 9 to 5 office worker.