Humberside, what charters it does have, seem to generally do quite well - In Summer 18 though, only regular charters will be TUI to Palma, and Balkan to Bougras, plus a weekly Flybe to Jersey. The Jetxtra departures to Alicante operated by BA Cityflyer have been canned this year though.
Ryanair have tried HUY a couple of times, with a Daily Dublin in the mid 00s' which didnt do very well (aircraft too large!), and a twice weekly Alicante, which appeared to do OK until Ryanair and Alicante airport had a dispute, and the route was dropped and never returned.
KLM to Amsterdam continues to do quite well, Eastern to Aberdeen did well up until a couple of years ago when the oil price fell, now it seems to be treading water, as many other Aberdeen routes seem to be doing.