There was the Cessna 182 accident that sadly killed those on board at Leicester, they believe pilot accidentally operated the autopilot button when advancing the throttle or adjusting the transponder, thus allowing the trim to run all one way. This was fixed with audible warnings and a requirement to hold the button for a given time period to turn it on and I had to replace the unit on our aircraft..
The report is here
https://assets.publishing.service.go...pdf_501522.pdf