Accidents can have the most trivial causes, an Eastern Airlines TriStar crashed into the Florida Everglades because of a burnt out light bulb which triggered a chain of events leading to the disaster.
Obviously the bulb blowing didn't cause the crash but what happened as a result of it did.
How many of us have heard a 02/20 clearance read back wrongly when operating into an airport with this runway orientation ? I have heard it regularly.