Some additional thoughts, presuming a reasonably limiting runway -
(a) if there is no difficulty with the aircraft's handling, then using the higher weight figures ought not to create a problem. From an accel stop point of view, the actual distances should be better at the lighter weight, providing some useful pad.
Desirable considerations-
(i) dry runway at an airport with a difficult escape path and lots of nasty terrain - one might prefer to stop.
(ii) at the higher V2 the aircraft's actual OEI climb gradient should be better than at the lower V2 (in the nature of an overspeed V2 takeoff) - useful if the obstructions are late second segment, but less so if they are early second segment.
(b) the lower weight figures would be desirable if the runway is wet and/or the overrun is nasty.
(c) one ought not to mix the lower V1 with the higher Vr/V2 unless you have additional data to make sure that the OEI TODR doesn't push out too far.
Safer ? ... if we accept that safety is the inverse of risk, then it comes down to a more global assessment of what is most likely to kill you soonest.