TBH I think TAngoAlphad is on the money and certainly even on the more user friendly modern Boeings a non pilot, or even a low houred PPL, would be pushed and certainly need a lot of luck to salvage the situation, and would certainly need talking through the button pressing and configuring by someone familiar with the machine.
If... if, prior to pilot incapacitation a complete route (with no holds embedded) to an ILS runway had been loaded into the FMC then maybe with "coaching" by R/T being given with regards to gear, flaps and control panel settings maybe a survivable auto land would be possible....but the minute you end up with say something simple but unforseen happening e.g. an ALT capture at top of descent or in the descent then I suspect a complete tyro would be up against it. It's also worth considering on most sectors you haven't got fuel for more than perhaps two or three abortive attempts at an ILS at destination.
Last edited by wiggy; 20th Aug 2017 at 08:43.