As with everything, there are some who like it, some who hate the long haul lifestyle. Having spent over 10 years on SH, I can honestly say I'll never willingly return to fly SH.
LH has its challenges, but then so does SH. The tiredness is perhaps different, as you're often getting up at midnight to go to work, and there are several nights a month sitting in the seat. On the other hand, if you can get the hang of controlled rest, and being able to sleep at odd hours of the day, it's perfectly manageable. I know there are people who just can't adjust to the change in sleep patterns, and these often return to SH.
From a flying perspective, being a long way from a suitable diversion airfield and coping with the complete lack of radio and radar coverage in some parts of the world takes a bit of getting used to. You're definitely on your own in certain areas.
The jets of course are bigger. But really it's just another machine to fly. No big deal.