The technology exists to fly a large passenger aircraft from A to B without a pilot on board.
There would most likely need to be a pilot/operator on the ground monitoring the flight. That person would also probably have to deal with the various documents/certification required to legally operate the flight.
The real issue is would the travelling public get on board? I suspect some would, some wouldn't and the balance is likely to change over time as society gets used to more automation in general. For it to become 'the norm' would, I imagine, take decades - it may never reach that stage.