As far as hypoxia, after a cabin decompression is concerned: Wouldn't it be usual to keep the a/p in for the descent, and dial 10,000 (or higher?) into the MCP? (Useful consciousness 20-30 secs?)
In which case the a/c would level at that altitude, and fly to fuel exhaustion/impact with terrain?
I accept, everything currently known seems to tally, but a significant number of possibilities are still very much in play. No doubt the talking heads on TV will be able to explain all!