Cognoscenti
OK, I will put my head over the parapet!!!!!
I havent a clue about many of the terms you use. That is not a judgement, merely to reflect that after 30 years in mainstream medicine, involved in basic physiological research, I have never heard of any of this. I would be interested in the publications and papers you read.
I think the big issue is that, although there are some genes which predispose to specific illnesses - breast cancer being one - we cant say one gene is bad or good. Nor can we turn them off. If we could do so, cancer is just one disease that would disappear. The big unknown is why a cell misbehaves. The gene pool is unchanged, and any variances are relatively minor over short periods, but suddenly a catastophic error occurs.
If you can answer that I can give up medicine and fly full time!!