Iberia have dipped their toe in & out of MAN-MAD & couldn't make it work even with a CRJ. I don't think BA / IB have any interest in connecting any of the regions with MAD. They could have done that before, the tie up with BA does not make it any more likely.
A solitary RYR flight that does not arrive into MAD until 2225 would not impact in that kind of market.
I won't be using any RYR service, but good luck to those who do want this kind of operation.