These aircraft may fly missions without the constant threats that AH/SH face, but the fatigue issues are considerable. They will have to remain airborne for very long periods without any respite, the missions will be mundane and busy a flypro will wear the crews down. Good crew rest will be essential for flight safety on sustained Ops, we will be out there for many years to come.
Although aircon might prevent full aclimatisation, it is essential if you need to sleep in the heat of the day. The effects of heat and fatigue will degrade anyone, and eventually lead to an incident.