I have flown all types mentioned. The Seneca I does not have good single engine climb performance. The Aztec is a big bus with 50s style technology but lots of people like the roominess in them. The Twin Com would be my favourite if it is the PA39 rather than the PA30 - the latter has a vicious stall.
But if you had a choice, then the Seneca 3 has far better performance and my current favourite twin is the BE76 Duchess - a very good training and touring aircraft with 25 knot crosswind capability.