Ask yourself honestly if your wife will be happy sitting there for 2 days getting bored out of her mind? You will have driving to keep you occupied and you may enjoy the scenery, but she will be unbelievably bored! Have you seen how far it is? Fly, and drive and enjoy the sights when you get there. Grand Canyon, Meteor Crater at Winslow, Sedona, Hoover dam. Those places are still an immense distance. If you drive the boring bits, you won't have the energy left for the good bits.