The 4-wheel taxi turns would have to be kept really really gentle - we often needed a little in-turn cyclic against the trim on some of the narrower taxiways to avoid roll cross-coupling, which wouldn't be possible with your arrangement, SASless. Your knowledge certainly still applied with the D and its equivalent(s) elsewhere. Agree re the emergencies - cockpit actions while one pilot flies the aircraft with HYD out spring to mind. Wouldn't be able to reach the Master Armament switch from the LHS, but that's probably not a consideration for these C130/KC46 tasks either.
Thanks, ExA re double assymetric; saw your earlier comment, was just wondering if there were any ground-manouevring handling considerations (unless, of course, you are saying that double-assymetric is a problem on the ground, too).