Someone mentioned MCAS as an example of technical failure. My take on that is that it was a technical failure which only came about due to the requirement to make the aircraft feel the same to the pilots. No pilots = no MCAS...
When Airbus gets automatic optically guided flight sorted out, which it inevitably will, the clock will be ticking for professional piloting as we know it. If the cost is that the next Miracle on the Hudson turns into a disaster because the computer couldn't work out what to do, the benefit of having avoided the dozens of pilot error accidents that would have happened in the meantime will have been worth it.