it is possible. I know a few examples:
Cessna Citation Bravo to Dash 8-400
Citation CJ3 to Airbus A320 (straight to the left seat...)
Embraer Legacy 600 to Airbus A320
and so on. Hours on aircraft above 20T will help alot.
It depends on the timing and market situations. Most Airlines avoid direct entry Captain positions and promote internal upgrades which works better for them and keeps the workforce happy...