Just looking at last night’s destinations comes up with 10+ single rwy airports. Not all huge it is true, but serving big cities GVA BSL SOF. others OPO BLL VNO NTE ORB AOI RIX SKP.
Flight Detent is right - PRG has a long way to go to compete with LTN as a destination!
Also true is (can be) the effect of losing one of the rwys. A few years ago the ac ahead of me on approach declared a Mayday, engine failure, continuing to land. We went around and asked for the other rwy and were told that due fire services involved on the S rwy that the airfield was closed.