I suspect the biggest problem long term for the A380 is it's USP in the first place. The floor beams for the upper deck. That alone plus the placement of the Flightdeck mean it's no freighter and never will be. There are a lot of 10-15 year old B744F and BCF out there, carrying outsized freight the world over. There really is only one option to replace them, and Boeing know it.
A380? Well, they'd make a grand firebomber....