The usual route in the UK has for many years been DRE. PSA. TRUSS Biopsy. MRI. Bone scan (if PSA is over 10) and then treatment.
This has resulted in a lot of men being rodded and radiated unnecessarily (both in the UK and USA) so there is a move now to do the MRI before the biopsy and to use the Targeted Transperrenial method of biospy to provide greater accuracy.
One thing to beware of is that some hospitals insist on using a trace agent to enhance the MRI. This invariably contains a toxic heavy metal called Gadolineum which is supposed to be flushed out through the kidneys. (Kidney function is checked first) However there is growing evidence that it doesn't all come out and that some remains lodged in muscles and the brain. The consequences of that are unknown at present although a lot of patients complain of multiple problems. The medical profession is burying its head about it but certain types of agent have now been banned in Europe and the FDA is moving toward accepting that they can have serious consequences. If you are offered a 'Trace MRI' ask if you can avoid it until further evidence comes to light.