The AN225 certainly comes with its own towbar as does the AN12/22/124's operated by ADB.
There is no problem fuelling the 225 as it can be hydrant or bowser tanked. MRYIA has operated into PIK and there was no problem there, EMA are ok with the aircarft as are MAN, although STN won't let the aircraft due to the small size of the airfield and the wings impinging on the runway when on the taxyways. MRYIA also has operated into a lot of European airfields with no problems. The footprint is also lot less than a747!!
Altogether a fairly versatile aircraft with a second one under construction. The 380 also has a problem in that it does not have a nose door ala 747 and will load through two side doors. The 225 with a nose door and kneeling nosewheels can load direct onto the aircarft without the need for highloaders.
Not that I am biast of course but the 380 will be OK with the likes of UPS etc but it will never compete withthe 225