The 742F comes in both 2- and 3-pack configurations. Our SOP is to run only 2 packs in cruise unless livestock is on board a 3-pack airplane.
The 744F packs are different, and normally run at a low-output setting in cruise. All 744Fs have 3 packs,
AFAIK. They can manually be set to high output, and will automatically do so in certain settings of lower compartment temperature control or if 1 pack fails.
Our SOP is that all packs must be operational to take off with livestock, regardless of airplane configuration.