On a purely transporting kgs of fuel vs. kgs of payload basis yes. Anyone who has access to flight plans can easily demonstrate that. Therefore the myth of the 380 being the most ecological aircraft is bullocks.
On a yield basis it is hard to prove, as the cost of crew, overflight/landing/parking fees, maintenance is not well perceivable for outsiders.
Generally there is the understanding that if you fill the 380 with the intended prime passengers, it will be more profitable. If however you don't, or upgrade too many low paying customers, you lose profit faster than on a T7.
It also comes down to how much the 380 is still subsidised by AB for the over burn .....
I guess on trunk routes up to 9 hours the 380 makes money.
Beyond that it gets harder.