Milan Linate 2001, departing aircraft collided with another aircraft on the ground and ended up in a building. More on
Wikipedia.
There are protected areas around runways to ensure no objects (or at least only small, breakable ones like light fittings) are in the areas most likely for an aircraft to depart from the paved surface. There are also protected surfaces extending upwards and outwards from the runway for the same purpose. The subject is very complex, but the CAP 168 (available free on the CAA website) is the definitive document for the UK if you want to read more about it (and is also a good cure for insomnia!).