As early as 1974 we had an unclassified targetting exercise on the WEC. Our target was an airfield in east Germany. Our available weapons included the B57 and a Nike-Hercules amongst others.
Considerations were the airfield had 4 dispersed HAS sites and runway redundancy. We concluded that a single B57 would not be suitable for the task. The weapon of choice was the N-H in airburst mode. It offered the biggest yield and the potential to disrupt operations at all sites. It had the benefit of destroying a large part of the adjacent town.
Now it doesn't need an Einstein to look at a map, arc off RoA for different aircraft types, and draw up a list of target sets. The meat that TJW probably wants is the fact that targets had backup aircraft allocated as well as a primary. For instance I was told that an F104G primary target might also have an F4M allocated is the 104 went US. This created a problem as the F104 route and attack speed was greater than the F4M.