We operate a C421 C. If you don't want to carry a decent load and you don't want to get there too fast, then the 421 is your plane. Its nice to fly, but ours can't take more than 3 people with full fuel. Its TAS in the teens is around 200kts. I find it very slow to climb unless its very light and the temps are very cold. If the temps are very cold, then beware the engine shock cooling... keeping them engines warm involves a 200fpm descent rate in our WI winters.
Asides from all that, its a nice aeroplane