I'm on the cheapest and nastiest Eee model (4G is it called?), the one with the solid state drive. It's absolutely fantastic to take on the road. I'm using it with their standard Xandros distro + a little bastardisation (extra packages from Debian repos, etc.) and booting into the so-called "Full Desktop" (i.e., standard KDE 3.4).
I found it handy to create a custom key combination to make windows full screen (you can always do it through the window's menu, but it's quicker using the keyboard), and modified Thunderbird so that it only shows two address lines (shrinkable to one), thus gaining valuable screen real estate when composing mail.
I've also switched all my e-mail accounts to IMAP, so if the thing gets lost/stolen/ran over there should be minimal if any data loss.