The problem with all chemoprophlaxsis against malaria has been side-effects.
Malarone is a new and potentially useful combination of two drugs Proquanil and Atovaquone.
These two drugs have been used in isolation previously and have shown to have side effects.
Primarily and most commonly this is Kidney Dysfunction, which is often compounded by the relative state of dehydration that is often found in people visiting Malarious areas. (Hint drink lots of fluids)
I am very cautious of new medications that tout little side effects, especially when they are simply reformulations of existing medications that have been shown previously to have them. A bit like mixing snot and sugar and calling it icecream.
I am currently practising in a malarious area and NONE of the pilots (HM Forces) who I tend to are taking Malarone! It may well be a safe and effective drug, however in the environment that I am in maybe is just not good enough.
Whatever you decide to take is up to you, just take something. A recent study in the Congo has shown that by taking nothing you are at 6% risk of contracting Malaria following a 2 week stay.
But as I said talk to your AME or GP who will put you on the right track.
Cheers
Itis