Not my story, second hand from a mate - but I'll tell it anyway.
An RAF Hercules many years ago with my mate as the FE was due to fly from Colombo to Singapore empty, but at the last minute some frieght showed up in the form of an RAF police dog with it's handler. The dog had an abcess on a tooth which was going to be treated in SIngapore and was loaded in a wooded kennel crate.
In the climb, the dog's abcess got a bit painful as the pressure reduced. The dog went apesh!t and smashed it's way out of the crate. The crew barricaded themselves on the flightdeck and suggested to the handler that he should go back and calm it down.
"**** Off, h'ell eat me" was the reply.
So the solution was to go onto oxygen, depressurise, wait until the dog passed through hypoxia out than lash it to the floor!